"If you over-esteem great men, people become powerless. If you overvalue possessions, people begin to steal. The master leads by emptying people's minds and filling their cores, by weakening their ambition and toughening their resolve. He helps people lose everything they know, everything they desire and creates confusion in those who think that they know. Practice "not doing" and everything will fall into place."
Unfulfilled desire may be the large part of unhappiness. Wanting and not receiving may be unsettling. One might spend some time in contemplation and look at the things they desire and see how they may only bring temporary satisfaction or pleasure. When one is empty, one is full. When you lose everything, you gain much more.